BASF Innovation Secures – Strong Global Position in Crop Protection Segment

BASF expanded its pipeline of solutions for agriculture significantly and by 2028, will launch innovations with projected peak sales of more than €6 billion. The pipeline contains a wealth of chemical and biological crop protection products, seeds and traits, as well as digital solutions.

This will further strengthen the company’s leading position in innovative and sustainable agriculture. BASF’s innovation pipeline demonstrates tangible progress based on continuous investment in research and development, the integration of acquired businesses, and strong partnerships.

In 2019, BASF will spend around €900 million on R&D for agricultural solutions. These are BASF’s new innovating pipeline products to strengthen the crop protection segment.

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Luximo® is a new herbicide product from BASF, with active ingredient Cinmethylin, which has received the first new mode of action classification from the Herbicide Resistance Action Committee (HRAC) since 1985.

Luximo® already approved for sale in Australia in 2019, BASF also expects farmers in the EU and UK to benefit from this much-needed herbicide in the future.

Luximo is the first active ingredient in the new HRAC mode of action class “Group Q” or “30”, which stands for the inhibition of the enzyme family Fatty Acid Thioesterase (FAT). These enzymes are vital for plant cell membrane development and function. Their inhibition disrupts germination and thus the emergence of grass weeds.

Luximo® has a novel mechanism of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis. It is positioned as a specialist grassweed herbicide, with a unique mode of action that will help maintain the effectiveness of integrated weed control programs.

Luximo active ingredient, Cinmethylin, provides pre-emergence residual control against a broad range of grasses, including persistent blackgrass and ryegrass in winter cereals.

• Luximo®herbicide –a much needed new tool from BASF for grass control in cereals
• Luximo® for the crop Wheat, Canola, Sunflower, Rice
• Novel mode of action against grass weeds
• Ensures sustainable wheat production endangered by increasing grass resistance
• Residual control of cool-season grasses with selectivity in cereals
• Consistently matches or outperforms market standards solo and in mixtures
• Novel mode of action for resistance management
• Dossiers submitted in EU28 and Australia

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Tirexor®herbicide – is a new protoporphyrinogen oxidase (PPO) inhibitor herbicide, its active is Trifludimoxazin that controls PPO-resistant weeds including pigweed and ragweed species.

The herbicide is fast-acting, with foliar effects that can occur in as little as one day. Tirexor’s anticipated global use includes application on small grain cereals, corn, soybeans, pulse crops, oil palm, and numerous tree fruit and nut crops.

It is the first new MoA for the foliar burndown of grass weeds in 20 years.

• Adding grass control to PPO inhibitors, delivering excellent broad-spectrum control in burndown
• A new tool to control resistant weeds based on PPO inhibition
• Unique control of PPO-resistant weeds for North and South American markets, including tough-to-control pigweed and ragweed
• A new mode of action in the Australian cereal market to control two broadly resistant weed species
• Potent mixture partner in burndown and residual applications, fast-acting: foliar effects can occur in
• as little as one day
• The wide array of crops, e.g. Wheat, Canola, Sunflower
• Dossiers submitted in the U.S., Canada, Mexico, Australia
• First market launch expected in Australia 2020, other countries from 2022

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Revysol® fungicide is the first Isopropanol-Azole being introduced to the market. Its active ingredient Mefentrifluconazole, belongs to triazoles fungicide class

• Mechanism of Action (MOA): Inhibition of ergosterol biosynthesis, by inhibition of C14-demethylase (SBI Class I).
• Revysol is highly effective against important diseases, such as Septoria tritici and rusts in wheat or Ramularia in barley.
• Molecular design leading to top performance: release properties from inner-leaf reservoir provides a long-lasting protection
• Formulations tailored to maximize outstanding and quick action with strong curative efficacy
• New and essential tool for resistance management
• Broad disease and crop spectrum, further registrations will cover other important crops such as oilseed rape, corn, fruits, grapes and vegetables.
• BASF gains approval for fungicide innovation Revysol® in Europe,
• First product launches for use in cereals expected in 2019/2020,
• Global peak sales potential above €1 billion,
• ~1,000 times higher target specificity (enzyme inhibition in fungi versus vertebrate cells) – setting a new standard for azoles
• Satisfies highest approval standards within its group of active ingredients
• Passes state-of-the-art endocrine disruptor criteria

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Inscalis® insecticide –new insecticide based on fermentation with favorable environmental profile. Its active ingredient AFIDOPYROPEN.

Meiji Seika Pharma Co., Ltd. announced that they have licensed  novel agricultural insecticide Inscalis® to BASF (registered trademark by BASF, ISO name: Afidopyropen, development code: ME5343), received the U.S. Environmental Protection Agency (EPA) registration for its Inscalis® insecticide, which was submitted application on March 2016.

Afidopyropen was discovered through research on microbial metabolites in collaboration with Meiji and the Kitasato Institute and Doctor Satoshi Omura group, which is a totally different insecticidal active ingredient from existing insecticides with a unique chemical skeleton and its insecticidal mode of action is classified into a new subgroup, 9D, by IRAC (Insecticide Resistance Action Committee) classification.

Afidopyropen provides effective control of insect pests such as aphids, whiteflies and psyllids. At present, afidopyropen is registered for soybean, cotton and a variety of fruits and vegetables in the U.S. The insect pests damage crop yields and lower the values of harvests by piercing and sucking plants, as well as mediating plant virus diseases. Afidopyropen decreases the occurrence of plant virus disease by quick onset of action. Although the problem of resistance to existing insecticides is increasing, afidopyropen controls those insecticide-resistant pests as well. Furthermore, since afidopyropen has a minimal impact on honeybees and as its application dosage is low, it can contribute to sustainable agriculture with the less environmental burden. In the U.S., one of the largest markets for afidopyropen, two products that meet farmers`’ needs for a variety of crops, are anticipated to be widely extended.

Inscalis® was launched in Australia and India in July, 2018, and BASF anticipates further registrations in Canada, Mexico, Argentina, and China.

• New tool for resistance management
• High efficacy at low rates, long residual
• Quick onset of insect feeding cessation leading to reduced virus transmission
• New chemical class, unique mode of action
• Favorable environmental profile with low toxicity to pollinators and beneficial arthropods
• Piercing-sucking pest spectrum
• Wide range of crops

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Vedira™  –new insecticide based on Broflanilide, which is a Meta-diamides / GABA-gated chloride channel allosteric modulator.

BASF has co-developed Broflanilide with Mitsui Chemicals Agro, Inc. This active ingredient is a powerful and versatile new mode of action insecticide to control chewing pests. Initial market launches are expected in 2020.

Broflanilide received the first registration worldwide by the Australian Pesticides and Veterinary Medicines Authority (APVMA). Co-developed with Mitsui Chemicals Agro, Inc. (MCAG), the active ingredient is a powerful and versatile insecticide for use in crop production as well as to control urban and rural pests.

Pest management professionals in Australia will be the first to benefit from this innovative solution, with products marketed under the Vedira™ brand. Further registrations, for uses in crop production, are anticipated in the U.S., Canada, Mexico and India, with additional registration submissions planned in upcoming years for key markets.

Broflanilide is a compound with a novel mode of action (IRAC Group 30), demonstrating excellent efficacy in the control of many problematic chewing insect pests, including caterpillars and beetles in specialty and row crops, and non-crop pests such as termites, ants, cockroaches and flies. It has potential use applications in cereals as a seed treatment for control of wireworms, as well as for foliar use in leafy and fruiting vegetables, potato, soybean, cotton, corn and legumes.

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