Epyrifenacil – Sumitomo Chemical Co., Ltd Experimental Advanced Candidate – phenyluracil herbicide – A protoporphyrinogen oxidase (PPOX) inhibitor

Epyrifenacil – New ISO common name provisionally approved in March 2020.

• Innovator: Sumitomo Chemical Co., Ltd
• Code Name: S-3100
• CAS REG. RN.:     353292-31-6
• Mechanism of Action (MOA): Protoporphyrinogen oxidase (PPOX) inhibitors
• IUPAC:         ethyl [(3-{2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)pyrimidin-1(2H)-yl]-4-fluorophenoxy}-2-pyridyl)oxy]acetate
• Chemical Class: Herbicides (Phenyluracil herbicides)
• Other Compounds in Phenyluracil Herbicide Class: Benzfendizone, Butafenacil, Epyrifenacil, Flupropacil, Saflufenacil, and Tiafenacil

Commercialization Commentary :

Sumitomo Chemical Co., Ltd., Japan has filed a PCT patent application (EP1122244A1; Est. Exp.: Feb 02, 2021 (Product Patent Family) covering Epyrifenacil long back in 2001. The compound patent is going to expire on Feb 02, 2021; however, data exclusivity and supplementary protection certificate may increase patent life a few more years.

Sumitomo is continuously filing method of use, combination (mixture patents) patents to protect their interest.

BASF has filed a PCT patent application on Epyrifenacil polymorph (Form A) in 2018 (WO2018178039A1), there are various mixture patents from BASF, wherein Epyrifenacil as mixture partner is considered.

Syngenta also filed a process patent in 2007.

These facts show Sumitomo and BASF are interested to protect IP near to Epyrifenacil as they are continuously patent applications on Epyrifenacil.

Epyrifenacil Compound Patent details:

1. Patent Number: EP1122244A1; Est. Exp.: Feb 02, 2021 (Product Patent Family)

Assignee: Sumitomo Chemical Co., Ltd., Japan

Publication Date: 2001-08-08

Application Number: EP2001-102178

Application Date: 2001-02-02

Equivalents:

AR027938A1; AR078875A2; AT277910T; AU1676001A; AU779561B2; BR0100318A; BR0100318B1; CA2334399A1; CA2334399C; CA2646796A1; CN1316426A; CN1204137C; CN1636981A; CN1328261C; DE60105859T2; DK1122244T3; EP1122244A1; EP1122244B1; ES2226990T3; IL167954A; IL167955A; IL167956A; IL167957A; IL167958A; JP2002155061A; JP4356247B2; JP2009209147A; KR20010083158A; KR100673344B1; MXPA01001317A; PT1122244E; TR200402577T4; US6537948B1;

Indian Equivalents: Not Found

Title: Synthesis of uracil derivatives (e.g. pyrimidinyl-aryl-pyrimidinyloxy-acetates) as herbicides

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