March 2024, New poster is released by the Fungicide Resistance Action Committee (FRAC), revealing the inclusion of Group 54, Benzoxaboroles, in the MOA D focusing on amino acids and protein synthesis. The specific target site and code for this compound is D6 leucyl-tRNA synthetase (LeuRS).
Key details from the poster include:
- Common Name: Tavaborole has been added in FRAC 2024 Poster under the new MOA D: Amino Acids and Protein Synthesis.
- Group Name: Benzoxaboroles
- Chemical or Biological Group Name: Benzoxaboroles
- Target Site and Code: D6 leucyl-tRNA synthetase (LeuRS)
- Note: This compound poses low risk, primarily due to its exclusive post-harvest application.
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About Tavaborole: Tavaborole Belongs to the benzoxaborole class and classified as an organofluorine compound, originally developed by Anacor, tavaborole is now marketed in the United States by Novartis subsidiary Sandoz. The patent for Tavaborole was initially filed by Anacor Pharmaceuticals in 2006, and it is set to expire in 2026.
Its mechanism of action primarily revolves around inhibiting protein synthesis, rendering it an oxaborole antifungal agent.
Tavaborole demonstrates efficacy against Botrytis cinerea infection in postharvest fruit. Primarily utilized as a topical antifungal agent for treating onychomycosis, a fungal infection affecting toenails and fingernails, it functions by acting as an antifungal agent, inhibiting protein synthesis, and serving as an inhibitor of EC 6.1.1.4 (leucine–tRNA ligase).
About FRAC: The organization known as the Fungicide Resistance Action Committee (FRAC) was established by industry and research scientists to be an overseeing group to monitor fungicide resistance and provide guidelines for the development of products with long-term utility.
Fungicides have become an integral part of efficient food production. The loss of a fungicide to agriculture through resistance is a problem that affects us all. FRAC works to prolong the effectiveness of fungicides liable to encounter resistance problems and to limit crop losses should resistance appear.
This committee established the FRAC code, which identifies different target sites within specific modes of action for all active ingredients. Usually, there is a small rectangular box on every fungicide label where the FRAC number is located.
Different letters (A to P, with added numbers) are used to distinguish fungicide groups according to their biochemical mode of action (MOA) in the biosynthetic pathways of plant pathogens. The grouping was made according to processes in the metabolism starting from nucleic acids synthesis (A) to secondary metabolism, e.g., melanin synthesis (I), followed by host plant defence inducers (P), recent molecules with an unknown mode of action and unknown resistance risk (U, transient status, until information about mode of action and mechanism of resistance becomes available), and chemical multi-site inhibitors (M). Fungicidal compositions of biological origin are grouped according to the main mode of action within the respective pathway categories.
For more details visit ChemRobotics Discovery Platform – ChemRobotics.com (Global Agrochemical Intelligence Database)