Indomethacin is shown to be highly efficient in treating the Covid infection as per a study conducted by Dr Rajan Ravichandran, director nephrology, MIOT Hospitals and Prof R Krishna Kumar, Institute Professor, IIT Madras in India.
The study showcased the high efficacy of using Indomethacin in the early stages of Covid infection, especially in mild and moderate cases. It’s also a cost-effective medicine.
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The first trial, conducted during the first wave, had 144 RT-PCR positive patients statistically matched in two arms, one treated with indomethacin and standard care and the other with paracetamol and standard care. The second carried out in the second wave was a randomized control trial with 210 RT-PCR-positive Covid-19 patients. They were allotted to two arms, as above, based on block randomisation; 103 and 107 patients were in the indomethacin and paracetamol arms, respectively. The primary endpoint was the development of hypoxia/desaturation with SpO2 = 93, while fever reduction and cough and body pain resolution were the secondary endpoints. A third small trial treated 22 severe patients who required oxygen with indomethacin. No steroids were given to these patients.
The first trial was conducted at Narayana Medical College, Nellore and Datta Meghe Institute of Medical Sciences, Wardha, and the second trial took place at Panimalar Medical College, Chennai.
About Indomethacin
Structure
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.
It was patented in 1961 and approved for medical use in 1963. It is on the World Health Organization’s List of Essential Medicines. It is marketed under more than twelve different trade names. In 2017, it was the 291st most commonly prescribed medication in the United States, with more than one million prescriptions.
Medical uses
As an NSAID, indometacin is an analgesic, anti-inflammatory, and antipyretic. Clinical indications for indometacin include:
Indomethacin is used to relieve pain, swelling, and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of certain natural substances that cause inflammation.
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