IRAC Poster/Classification Version Edition 11.1
This edition addresses the pending registration of Active Ingredients since the last update in September 2023. Among the unassigned groups from the previous update, Groups 26, 27, and 35 were awaiting assignment.
In the latest development, Group 35, specifically focusing on RNA Interference mediated target suppressors with the active ingredient Ledprona, has now been assigned and incorporated into the new poster edition. Consequently, Groups 26 and 27 remain unassigned currently.
Updated Poster Notes:
- Sub-group 3B: DDT is no longer used in agriculture and therefore this is only applicable for the control of insect vectors of human disease, such as mosquitoes, because of a lack of alternatives.
- Sub-group10A: Hexythiazox is grouped with Clofentezine because they exhibit cross-resistance even though they are structurally distinct. Diflovidazin has been added to this group because it is a close analogue of Clofentezine and is expected to have the same mode of action.
- Group 20: While there is strong evidence that Bifenazate acts on the Qo site of Mitochondrial Complex III and some Bifenazate resistance mutations confer cross-resistance to Acequinocyl, the sites of action of Fluacrypyrim and Hydramethylnon have not been determined.
- Groups 26 & 27 are unassigned.
- In some cases, only representative actives are shown.
- Because of documented cross-resistance between dicofol, bromopropylate and abamectin, these active ingredients should not be rotated after each other in an IRM program.
Ledprona is developed by GreenLight Biosciences, USA. Ledprona is a sprayable double-stranded RNA biopesticide, assigned CAS RN. 2766607-82-1 with a new mode of action that triggers the RNA interference pathway.
Ledprona, the active ingredient in GreenLight’s CalanthaTM product, is approved as a new mode of action in the recent winter meeting of IRAC, an international association of crop-protection companies that focuses on resistance management and sustainable agriculture.
The first foliar-applied, dsRNA-based bioinsecticide that provides effective control of CPB, CalanthaTM is expected to be registered in the United States this year. The Colorado potato beetle (Leptinotarsa decemlineata) ravages plants like potatoes and eggplant and accounts for more than $500 million in annual crop loss worldwide.
For decades, insect resistance to pesticides has challenged growers. Using integrated pest management, which includes rotating insecticides, farmers and agronomists can prolong the useful lifespan of crop treatments. GreenLight’s product is designed to work well with standard growers’ programs to control first- and second-generation Colorado potato beetle infestations.
CalanthaTM has a unique mode of action among chemical and biological insecticides, which will provide farmers with a new tool aimed at protecting potato and eggplant fields from the Colorado potato beetle and supporting their efforts at resistance management.
Ledprona, expected to be classified as IRAC MoA group 35 (RNAi-mediated targeted suppressors), specifically targets only CPB, causing the beetle to stop eating and expire from the accumulation of its own metabolic waste. Because it is based on double-stranded ribonucleic acid, CalanthaTM degrades quickly in the environment, supports biodiversity, and is an example of the next generation of eco-friendly crop-protection products.
The Insecticide Resistance Action Committee helps growers around the world by developing mode-of-action classification schemes; identifying new technologies for insect, mite, and tick control products; and implementing insecticide resistance management strategies for crop protection, plant biotechnology, and public health.
For More Detail Visit: ChemRobotics.com (Global Agrochemical Discovery & Generic Intelligence Database)