Insecticide Resistance Action Committee (IRAC) Mode of Action Classification – 2020 Published

About IRAC: The global authority on Insecticide Resistance Management (IRM) – a strategy for Sustainable Agriculture and improved Public Health.

1.1.          The IRAC Classification Table – 2020 

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Table Notes:

1. The color scheme used here associates modes of action into broad categories based on the physiological functions affected, as an aid to understanding symptomology, speed of action and other properties of the insecticides, and not for any resistance management purpose. Rotations for resistance management should be based only on the numbered mode of action
2. Inclusion of an insecticidal agent in the classification above does not necessarily signify regulatorily
3. MoA assignments will usually involve identification of the target protein responsible for the biological effect, although groupings can be made where insecticidal agents share distinctive physiological effects and are structurally
4. Groups 26 and 27 are unassigned at this time and have therefore been omitted from the
5. An insecticidal agent with an unknown or controversial MoA or an unknown mode of toxicity will be held in group ‘UN’ or ‘UNB’, ‘UNE’, ‘UNF’, ‘UNM’, ‘UNP’, UNV as applicable until the evidence becomes available to enable the assignment to a more appropriate MoA
6. Actives in groups marked with an asterisk are thought not to share a common target site and therefore may be freely rotated with each other unless there is reason to expect cross-resistance. These groups are 8, 13, UN, UNB, UNE, UNF, UNM, UNP and
7. Different baculoviruses that target different insect orders may be used together without compromising their resistance management. Rotation between certain specific baculoviruses may provide resistance management benefits for some pests. Consult product-specific

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