NEW ISO CANDIDATE – ICAFOLIN-METHYL (ISO 1750) – BY BAYER CROP SCIENCE IN HERBICIDE CLASS

ICAFOLIN-METHYL

MOLECULE DETAILS:

  • STATUS: Modified ISO 1750 (provisionally approved)
  • IUPAC NAME: methyl (2RS,4RS)-4-({[(5S)-3-(3,5-difluorophenyl)-5-vinyl-4,5-dihydroisoxazol-5-yl]carbonyl}amino)tetrahydrofuran-2-carboxylate containing 40–70% of the (2R,4R)-isomer and 60–30% of the (2S,4S)-isomer
  • CAS REG. NO.: 2749998-21-6
  • FORMULA: C18H18F2N2O5
  • ACTIVITY: Herbicides (unclassified)

PATENT INFORMATION:

Icafolin esters and salts activities are disclosed in compound patents of Icafolin and International Patent applications, e.g. WO2018228985 and WO2018228986 are the compound patents of Icafolin filed by Bayer Aktiengesellschaft on 2018-06-11, and both patents were published on 2018-12-20.

Indian equivalents of the compound patents are IN411240B (IN201917046419) and IN411184B (IN201917046072), respectively.

Pre-emergence herbicidal studies of Icafolin analogs:

Compounds Nos. 1-21 and other compounds in the tables (for example, 1-10, 1-26, 1-09, 1-30, 1-28, 1-29, 1-27, 1-01, 1-06, 1-34, 1-32, 1-33, 1-19, 1-11, 1-12, 1-35, 1-36, 1-37, 1-38, 1-41, 1-42, 1- 43, 1-44, 1-46, 1-49) have a very good action (80% to 100% herbicidal action) against harmful plants such as Abutilon theophrasti, Alopecurus myosuroides, Amaranthus retroflexus, Avena fatua, Echinochloca crus, during preemergence treatment. gallium, Hordeum murinum, Lolium rigidum, Pharitis purpurea, Polygonum convolvulus, Setaria viridis, Stellaria media, Veronica persica and Viola tricolor at an application rate of 0.08 kg of active ingredient or less per hectare.

 Post-emergence herbicidal studies of Icafolin analogs:

Compounds Nos. 1-35 and other compounds from the tables (for example, 1-28, 1-38, 1-01, 1-19, 1-36, 1-29, 1-32, 1-11, 1-12, 1-37, 1-06, 1-09, 1-33, 1-34, 1-13, 1-04, 1-26, 1-21, 1-30, 1-05, 1-03, 1- 20, 1-27, 1-14, 1-10, 1-23, 1-07, 1-25, 1-02, 1-08, 1-24, 1-41, 1-42, 1-43, 1-44, 1-46, 1-49, 1-54, 1-55, 1-56)

Postemergence very good herbicidal action (80% to 100% herbicidal action) against harmful plants such as Abutilon theophrasti, Alopecurus myosuroides, Amaranthus retroflexus, Avena fatua, Echinochloa crus-galli, Hordeum murinum, Lolium rigidum, Pharitis purpurea, Polygonum convolvulus, Setaria viridis, Stellaria media, Veronica persica and Viola tricolor at an application rate of 0.32 kg of active ingredient or less per hectare.

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