Flumetnicam also known as TFNA-AM is a known environmental transformation product of Flonicamid. TFNA-AM is a potent chordotonal organ modulator.
- APPROVAL: ISO
- IUPAC PIN: 4-(trifluoromethyl)pyridine-3-carboxamide
- IUPAC NAME: 4-(trifluoromethyl)pyridine-3-carboxamide
- CAS NAME: 4-(trifluoromethyl)-3-pyridinecarboxamide
- CAS REGISTRATION NUMBER: 158062-71-6
- FORMULA: C7H5F3N2O
- ACTIVITY: Insecticides (Nicotinamide)
- SYNONYMS: 3-Pyridinecarboxamide,4-(trifluoromethyl)-;4-Trifluoromethylnicotinamide; TFNA-AM
The functional effects of TFNA-AM on chordotonal organs of locusts and flies are indistinguishable from those of the TRPV agonists pymetrozine, pyrifluquinazon and afidopyropen. According to previous results indicate that TFNA-AM does not act directly on TRPV channels, so it is concluded that it acts upstream in a pathway that leads to TRPV channel activation.
Syngenta has filed one method of use (MoU) Patent (See Details AgroPat Discovery Suite) in 2017 covering Flumetnicam and related analogues controlling nuisance, disease carrying or haematophagous (blood feeding) insects pests including dipteran, 5 triatominae and cimicidae insect pests by knockdown or by or blood feed inhibition. In one embodiment, dipteran pests are selected from flies and mosquitoes, including insecticide-resistant flies and mosquitoes, as well as fly and mosquito vectors of pathogenic disease. Target cimicidae insect pests are selected from bed bugs.
More specifically, the active compounds suitable for use in the active compound compositions, methods, products, treated substrates, and integrated solutions of the invention are selected from certain 4-(trifluoromethyl)pyridine compounds that are capable of being “picked-up” by target dipteran, triatominae and cimicidae insect pests and cause rapid knockdown of the target insect or inhibit the target insect from taking a blood meal if such insect is haematophagous.
In partciular, the inventive 4-(trifluoromethyl)pyridine compounds and related active compound compositions exhibit rapid knockdown or blood feed inhibiting activity against such insect pests without requiring oral administration such as by consumption of treated bait or other food source containing such compounds.
