DIMPROPYRIDAZ NEW INSECTICIDE FROM BASF SUBMITTED FOR REGULATORY REGISTRATION
Axalion (Dimpropyridaz) is pyrazole carboxamide class of insecticides. Dimpropyridaz chemically is a pyrazole carboxamide insecticide that has a pyridin-3-yl group, as in tyclopyrazoflor. Dimpropyridaz is effective against aphids. Dimpropyridaz mechanism of action is unknown.
BASF has announced that it has submitted regulatory dossiers for the new insecticide Axalion (dimpropyridaz) in Australia and Korea, with additional registration submissions planned for the EU, Brazil, and India in 2021, as well as other key markets in the coming years. Pending regulatory approval, BASF expects first market introductions of Axalion-based products from 2023 in Australia and Korea, 2024 in India, and 2026 in the EU.
Axalion (dimpropyridaz) is reportedly the sole representative of a unique class of chemistry discovered by BASF with a novel mode of action. The product will be registered for use in a broad range of crops in the fruits and vegetable markets, including grapes and potatoes, to control piercing and sucking insect pests, including whiteflies and aphids. Proposed uses of the product are also reported to be environmentally friendly with regard to soil and water organisms; beneficial insects, including pollinators; as well as birds.
Axalion™ product has excellent performance and can be conducted in plants. Axalion™ will be registered for many fruit and vegetable crops such as grapes and potatoes, soybeans, other legumes, cotton, grains and other field crops, as well as flowers and ornamental plants, etc., to effectively control many difficult-to-control piercing and sucking mouths Insect pests, such as whiteflies and aphids, these pests can lead to a substantial decrease in crop yields and farmers’ income.
Axalion™ can quickly stop pest feeding, reduce plant nutrient loss, prevent disease transmission, healthy plants, and improve crop yield and quality.
BASF has carried out a large number of demonstration tests, and the results show that Axalion™ is environmentally friendly to soil and aquatic organisms, and is harmless to beneficial insects such as pollinators and birds.
Dimpropyridaz chemically is a pyrazole carboxamide insecticide that has a pyridin-3-yl group, as in tyclopyrazoflor. Dimpropyridaz is effective against aphids. Dimpropyridaz mechanism of action is unknown.
ISO Status: Dimpropyridaz is an Insecticide with an unknown mode of action. ISO common name is given on Dimpropyridaz in December 2018.
IP (Patent Scenario):
Compound Patent (Product Patent Family):
1. WO2012143317 (BASF SE, Germany); Est. Exp. 16 Apr, 2032;
- Equivalents: CA2830138; CN103492378; EP2699563; JP5937199; BR 112013024708; WO2013156318; IN 7605/CHENP/2013 (IN 318567); US9198422; US9439427;
- Title: Novel pyrazole compounds as pesticides and their preparation.
2. Publication Number: WO2020144308 (BASF SE, Germany);
- Publication Date: 16.07.2020
- International Filing Date: 10.01.2020
- Title: (EN) Crystalline Forms Of 1-(1,2-Dimethylpropyl)-N-Ethyl-5-Methyl-N-Pyridazin-4-Yl-Pyrazole-4-Carboxamide
BASF recently published PCT patent application covering Form B dimpropyridaz. Dimpropyridaz exhibits polymorphism, e.g. Form-A & Form B. The polymorphic form-A is prior art form, which can be obtained by the following the process disclosed in the compound patent of dimpropyridaz as glassy melt, which contains the crystalline form A, e.g. WO 2012/143317.
Polymorphic Form-B of dimpropyridaz is more stable than polymorphic Form-A as per instant BASF patent application (WO2020144308).
Indian Registration Status:
Dimpropyridaz Name of the Molecules is Included in the Schedule, India Insecticide Act, 1968 in 57th Central Insecticide Board meeting held on 15.11.2019.
Evaluation of bio-efficacy of BAS 550 011 (dimpropyridaz 120 SC) against whitefly and cotton jassid and aphid, its phytotoxicity and effect on natural enemies in Bt cotton going at Punjab Agricultural University, which is funded by BASF.
- Chemical Name: 1-[(1RS)-1,2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazole-4- carboxamide
- Chemical Class: A pyridazine pyrazolecarboxamide compound
- CAS Registration Number.: 1403615-77-9
- Activity: An experimental insecticide
- Formulation: Dimpropyridaz 120 SC
Toxicity Studies Data submitted in CIB Meeting (Central Insecticide Board and Registration Committee):
- Acute Oral LD50 for Rats >2000mg/kg
- Acute Dermal LD50 for Rats >2000mg/kg
- Inhalation LC50 for Rats (4H) –
- Skin Irritant (Rabbit) – Nonirritant Eye Irritant
- Mutagenicity – No data available
- Respiratory or Skin Sensitization – N
For More details: Subscribe AgroPat* (http://chemrobotics.com/)
§ AgroPat provides techno-legal solutions to Agrochemical Discovery and Generic industry. Access 5500 pesticides with chemistry, Biology, Regulatory, and IP info. (Designed for Business Development function). ChemRobotics launched nine different databases as per different functions need. Weblink: https://www.chemrobotics.com/
§ AgroPat platforms cover more than 4500 Active Ingredients (Al’s) with all information including synthesis (ROS), formulation, combination, innovator, patents including product patent, developer, utmost important biology data containing spectrum, MoA, DFU, toxicity, which can play a major role in decision making for any individual /company/ university/ industry. Provide aboriginal information, which enables product developers to know about the state of the art in relevant subject matter, which includes innovator Patent / Non-Patent literature, which is critical for the generic industry.
- AgroPat Open Access – Free access to everyone,
- AgroPat Lite – With limited information as per business function needs,
- AgroPat ultimate – With all technical and business information