Erysichrona is a double-stranded ribonucleic acid (dsRNA), a large molecule containing 497 base pairs that has been designed to control Grape powdery mildew, caused by Erisyphe necator (E. necator) Syn Uncinula necator and it is the most significant disease in terms of expenses for control and losses in quality and yield encountered by grape growers worldwide.
For example, powdery mildew management accounts for 74% of total pesticide applications by California grape growers and 17% of total pesticides used in California Agriculture (by weight of active ingredient). In California, the statewide cost of powdery mildew management in 2015 was approximately $239 million, including the costs of pesticide materials and application (Sambucci et al., 2019). E. necator is considered to be a high-risk pathogen due to its ability to develop resistance to fungicides from multiple chemical groups (i.e. sterol demethylation inhibitors, quinone outside inhibitors and succinate dehydrogenase inhibitors) within a few years (Vielba-Fernandez et al.2020). Fungal resistance to fungicides is a challenge in grape protection, and current practices heavily rely on the chemical treatments which are harmful to the environment and detrimental to human health.
- STATUS: ISO
- CAS NAME: RNA (Erysiphe necator – specific double-stranded interfering ES43)
- CAS REG. NO.: 3002952-14-6
- ACTIVITY: Fungicides (RNAi)
- INCHIKEY: FAMDHWVDBSQEMI-OLSQSGHJBA-N (sense strand)
CPVVDBXJGKVSNV-KVRAIGKKBA-N (antisense strand)
The structure is presented as the sequence of the purine and pyrimidine bases adenine (A), cytosine (C), guanine (G) and uracil (U).
Global Patent Protection
GreenLight Biosciences has filed an international formulation patent application comprising Erysichrona for the control of Erysiphe necator, which is set to expire in 2042.
For more detailed information on Erysichrona visit ChemRobotics AgroPat Ultimate Discovery Suite N Platform – ChemRobotics.com (Global Agrochemical Intelligence Database)
