New Agrochemical Discovery Candidates – New ISO Published in 2022 Spirobudifen (Acaricide) & Tiorantraniliprole (Diamide insecticides) 

April 2022 BCPC – Compendium of Pesticide Common Names published new Agrochemical discovery acaricides & insecticides Candidates on the Alanwood platform, which is now acquired by BCPC (the British Crop Production Council).

Spirobudifen is acaricide and belongs to the chemical tetronic acid class, already three other molecules from the class are published, e.g., Spirobudifen, Spirodiclofen, and Spiromesifen. Bayer is a pioneer in the tetronic acid acaricides class.

Spirobudifen – Acaricide (tetronic acid acaricides)

• STATUS:               ISO 1750 (provisionally approved)
• IUPAC NAME:    butyl 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl carbonate
• CAS REG. NO.:   1305319-70-3
• FORMULA:          C20H22Cl2O5
• ACTIVITY:            Acaricides (tetronic acid acaricides)
• INCHIKEY:            HEOYPZMAGQITRO-UHFFFAOYSA-N
• INCHI:   InChI=1S/C20H22Cl2O5/c1-2-3-11-25-19(24)26-17-16(14-8-7-13(21)12-15(14)22)18(23)27-20(17)9-5-4-6-10-20/h7-8,12H,2-6,9-11H2,1H3

IP SCENARIO:

Compound Patent

1. CN102060818 – Novel spirodiclofen compound and preparation method and application thereof

Applicants: Hangzhou Udragon Chemical Co., Ltd.

Abstract: The invention relates to a novel spirodiclofen compound and a preparation method and application thereof. The structure of the novel spirodiclofen compound is shown in a general formula I. The synthesis method of the novel spirodiclofen compound comprises the steps of: in the presence of an acid binding agent, in an aprotic solvent, reacting a compound with a structure formula II with chloro-carbonic ester with a structure formula shown in the description at room temperature, and separating and purifying a product to prepare the novel spirodiclofen compound. The novel spirodiclofen compound can be used for killing pests or mites.

Combination (Mixture) / Composition Patents

2. CN102763664 – Insecticide composite containing spirodiclofen and bifenazate

Applicants: Hangzhou Udragon Chemical Co., Ltd.

Abstract: The invention relates to an acaricide composite for agricultural use, in particular to an acaricide composite containing the first active ingredient of spirodiclofen and the second active ingredient of bifenazate. Compared with siple dosage, the acaricide composite has a remarkable synergistic effect on acarina, has good preventive and therapeutic effects on panonychus citri on fruit trees, cotton and vegetables, panonychus ulmi, tetranychus urticae, tetranychus cinnabarinus or carmine spider mite, can kill eggs, larva, nymphs and adults, and is favorable for delaying production of drug resistance of acarina.

3. CN103749521 – Insecticidal composition

Abstract: The invention provides an insecticidal composition. The insecticidal composition contains an active compound, namely spirodiclofen diester represented by a formula (I) shown in a drawing, and an active compound, namely lambda-cyhalothrin represented by a formula (I) shown in a drawing. The insecticidal composition is prepared through the binary compounding of the active compound represented by the formula (I) and the active compound represented by the formula (II), a synergistic effect on the control of insects is achieved, the dosage of the two active ingredients is lowered, the generation of resistance is delayed, and the control spectrum is expanded.  

Tiorantraniliprole – Anthranilamides [diamide insecticides class (pyridylpyrazole insecticides)]

Tiorantraniliprole from insecticides diamide insecticides class (pyridylpyrazole insecticides) is also published. Tiorantraniliprole is covered in Chinese patent CN103130770B assigned to Qingdao University of Science and Technology. Tiorantraniliprole belongs to 3,5-dihalo thiobenzamide diamide insecticides class.

Advantage of the Tiorantraniliprole and positive effect: compared with known anthranilamides, has beyond thought high reactivity to insects such as beet armyworms.

there are the advantages such as raw material sources is wide, synthesis cost is low, low toxic and environment-friendly, in agriculture, woods pest control, there is better overall properties.

• STATUS: ISO 1750 (provisionally approved)
• IUPAC NAME:    3-bromo-2′,4′-dichloro-1-(3-chloro-2-pyridyl)-6′-(isopropylcarbamothioyl)-1H-pyrazole-5-carboxanilide
• CAS NAME:         3-bromo-1-(3-chloro-2-pyridinyl)-N-[2,4-dichloro-6-[[(1-methylethyl)amino]thioxomethyl]phenyl]-1H-pyrazole-5-carboxamide
• CAS REG. NO.:   1442448-92-1
• FORMULA:          C19H15BrCl3N5OS
• ACTIVITY:            insecticides (diamide insecticides; pyridylpyrazole insecticides)
• INCHIKEY:            IEFALYLJMGPZJY-UHFFFAOYSA-N
• INCHI:   InChI=1S/C19H15BrCl3N5OS/c1-9(2)25-19(30)11-6-10(21)7-13(23)16(11)26-18(29)14-8-15(20)27-28(14)17-12(22)4-3-5-24-17/h3-9H,1-2H3,(H,25,30)(H,26,29)

IP SCENARIO:

Compound Patent

1. CN103130770B – 3,5-dihalo thiobenzamide insecticides

Applicants: Qingdao University of Science and Technology

Abstract: The invention discloses a kind of 3,5-dihalo thiobenzamide insecticides and its production and use, its structure is as shown in general formula I: in formula I: R 1be selected from Cl or Br; R 2be selected from methyl, sec.-propyl, allyl group; R 3be selected from H or Cl.Can be used for the control of agricultural or forestry pest.

Combination Patent

2. CN105766982A – AGRICULTURAL INSECTICIDAL COMPOSITION AND USE THEREOF

Applicants: Hangzhou Udragon Chemical Co Ltd

Abstract: The invention relates to a pesticide composition containing thiotraniliprole and thiacloprid. The pesticide composition is prepared by mixing thiotraniliprole and thiacloprid according to the weight ratio of 1-50:1-50, and the synergic function is obvious. The pesticide composition has the advantages that the effects of controlling myzus persicae and plutella xylostella are respectively 93.4-98.5% and 92.6-97.8% after the pesticide composition is applied for 5 hours; the effects of controlling tea lesser leafhopper and tea geometrid are respectively 74.9-96.8% and 91.3-99.6% after the pesticide composition is applied for 7 hours; the effects of controlling rice planthopper, chilo suppressalis and rice leaf folder are respectively 92.1-96.5%, 90.3-95.6% and 92.7-96.4% after the pesticide composition is applied for 10 hours; by simultaneously controlling the myzus persicae and plutella xylostella, the tea lesser leafhopper and tea geometrid, and the rice planthopper, chilo suppressalis and rice leaf folder, the control spectrum is expanded, and the function of one pesticide with multiple controlling effects is realized.

About: Hangzhou Udragon Chemical Co. Ltd.
Founded in 1998, Hangzhou Udragon Chemical Co., Lt. is now a nationally designated agrochemical manufacturer in China. It is specialized in the production and international business for agricultural chemicals and intermediates, especially triazole and strobilurin series fungicides and phenoxypropionic acid herbicide. We have passed the authentication of ISO 9001:2008 quality systems, achieved OHSAS 18001 certification, and reached the standard of Safety Production. In 2014, Udragon Chemical won 'Agrow Awards 2014' with the title 'Best company from an emerging region' in recognition of its agriculture excellence in its technology, product, and marketing development efforts.

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