Home Active Agrochemical IngredientAgrochemical Discovery Candidates (New ISO) AGROCHEMICAL DISCOVERY UPDATE – CORTEVA AGRISCIENCE’S NEW INSECTICIDE TIAPYRACHLOR || GRANTED PROVISIONAL ISO STATUS

AGROCHEMICAL DISCOVERY UPDATE – CORTEVA AGRISCIENCE’S NEW INSECTICIDE TIAPYRACHLOR || GRANTED PROVISIONAL ISO STATUS

February 2024, Corteva Agriscience obtained provisional approval for a new common name for their insecticide named tiapyrachlor, which is closely associated with tyclopyrazoflor.

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Tiapyrachlor, identified by developmental codes such as X12019747, XR-120, & XDE-120, is a potent small molecule exhibiting efficacy against a diverse range of pests. Ongoing research is focused on exploring its potential for insecticidal applications.

Tyclopyrazoflor, a recently discovered pyridinyl–pyrazole compound by Corteva, demonstrates exceptional activity against sap-feeding insects. A study has confirmed the outstanding effectiveness of tyclopyrazoflor in addressing issues related to sap-feeding pests.

  • STATUS: Provisionally Approved
  • Development Code: X12019747, XR-120 and XDE-120
  • CAS RN.: 1255091-74-7
  • IUPAC NAME: N-[4-chloro-2-(3-pyridinyl)-5-thiazolyl]-N-ethyl-3-(methylsulfonyl)propenamide
  • ACTIVITY: Insecticide
  • CHEMICAL CLASS: Propenamide
  • GLOBAL IMPACT: International Patents Filed

IP SCENERIO: Corteva Agriscience has filed an international patent application for tiapyrachlor, covering its composition, preparation method, and one or more crystalline forms. The patent discloses Tyclopyrazoflor (X12019747, XR-120, & XDE-120) pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides.

Biological Assays

The said international patent application discloses the bioassays over Green Peach Aphid (Myzus persicae), Sweetpotato Whitefly (Bemisia tabaci), Western Flower Thrips (Frankliniella occidentalis), Western Tarnished Plant Bug (Lygus hesperus), Neotropical Brown Stink Bug (Euschistus heros), Beet Armyworm (Spodoptera exigua), and Diamondback Moth (Plutella xylostella) which are good indicator species for a broad range of agricultural pests. The results with these indicator species show the broad usefulness of various pesticides (also referred to as active ingredients) mixed with Formula One in controlling pest insects.

Detailed Process of Tiapyrachlor and other global updates access ChemRobotics Discovery Platform – ChemRobotics.com (Global Agrochemical Intelligence Database)

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