- Dunad Therapeutics, a biopharmaceutical company focusing on the development of next-generation targeted protein degradation therapies, announces that it has entered a strategic collaboration and licence agreement with Novartis to generate orally bioavailable covalent and protein degrading small molecule drugs.
- Novartis to leverage Dunad’s proprietary platform to generate novel oral covalent and protein degrading small molecule drugs across multiple target classes
- Novartis has exclusive option to license, develop and commercialize resulting candidates for up to four targets
- Dunad to receive $24 millionin an upfront payment and equity investment, as well as research funding
- Dunad eligible to receive up to $1.3 billion in discovery, development, regulatory and sales-based milestones in addition to royalty payments
Dunad Therapeutics (“Dunad”), a biopharmaceutical company focusing on the development of next-generation targeted protein degradation therapies, today announces that it has entered a strategic collaboration and license agreement with Novartis to generate orally bioavailable covalent and protein degrading small molecule drugs.
Under the terms of the agreement, Dunad will apply its tunable and highly selective platform to generate novel covalent and targeted protein degrading small molecule drugs focusing on up to four drug targets agreed with Novartis. Dunad will also be responsible for program execution up to lead optimization. Novartis will contribute target and ligand knowledge as well as access to unique assays and models and will fully fund the research collaboration.
Novartis has an exclusive option to develop and commercialize products resulting from the research programs directed against up to four drug targets. Upon exercise of this option, Novartis will assume responsibility for future development, manufacturing and global commercialization of the small molecule therapeutic products generated against the agreed targets.
Dunad’s unique platform uses mono-valent small molecules to induce selective degradation of disease-causing and often undruggable proteins via direct modification of the target. The Company’s novel molecular approach is fully tunable to be selective and is underpinned by a target-class agnostic mechanism of action that is clearly differentiated from other targeted protein degradation technologies.
Dunad’s platform has the potential to generate orally bioavailable degrader therapeutics that significantly expand the frontiers of protein degradation targets.
Under the terms of the agreement, Dunad will receive $24 million in an upfront payment and equity investment, as well as significant research funding. Dunad will also be eligible for milestone payments that could aggregate to up to $1.3 billion and royalties.
Alongside the equity investment of Novartis, and the founding investor Epidarex Capital, BioGeneration Ventures (BGV) is joining Dunad as a new investor. Oskar Slotboom, General Partner at BGV, has joined Dunad’s Board of Directors.
What is protein Degrader?
Protein degraders are enzymes that disassemble and break down unneeded proteins. These enzymes are naturally existing in cells but can also be exploited and engineered in biotechnology to target specific proteins to degrade, thus, shedding light on a list of drug candidates.
What is protein degradation therapy?
“Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are molecular glues that can degrade otherwise unligandable proteins by orchestrating direct interactions between target and ligase.
Prof. Patrick Gunning, Dunad’s co-founder, acting Chief Executive Officer and Chief Scientific Officer commented: “We are thrilled to have entered this collaboration with Novartis, which has already established a world leading position in the protein degradation space. This deal highlights the clear benefits our platform promises for the development of next-generation targeted protein degrader therapeutics. We are confident that with our approach of inducing degradation via direct modulation of target proteins with mono-valent small molecules, we can significantly expand the boundaries of targeted protein degraders as a therapeutic modality.”
Dr. Diana Kraskouskaya, co-founder and Chief Operating Officer of Dunad, commented: “This collaboration is an important milestone for Dunad. It allows us to rapidly expand the impact of our platform technology to additional target classes and therapeutic areas, beyond Dunad’s own internal target pipeline. Our growing team is committed to advancing our internal pipeline and partnered programs directed against the most sought-after and previously intractable targets.”
Dr. Elizabeth Roper, Partner at Epidarex Capital, Dunad’s founding investor, and board director of Dunad, commented: “We are delighted to see Dunad’s growth continue with such a significant deal with Novartis. This collaborationprovides validation of Dunad’s differentiated protein degradation technology andexplores the full potential of this new modality as a therapeutic approach. We are also excited to welcome BGV and Novartis as investors to the syndicate and look forward to our continued collaboration with the team.”
About Dunad Therapeutics:
Dunad Therapeutics is a biopharmaceutical company focusing on the development of next-generation targeted oral protein degradation therapies. Dunad’s platform enables selective degradation via direct target modification using tunable mono-valent small molecules, allowing for the development of more drug-like, orally bioavailable and CNS-accessible protein degraders.
Dunad was founded in 2020 and is headquartered in Cambridge, UK with operations in both the UK and North America and is backed by founding investor Epidarex Capital as well as BioGeneration Ventures (BGV) and Novartis.
Novartis is reimagining medicine to improve and extend people’s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world’s top companies investing in research and development. Novartis products reach nearly 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis around the world.
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