Home Intellectual Property (IP)Patents US grants new patent targeting major neurodegenerative diseases

US grants new patent targeting major neurodegenerative diseases

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Alterity Therapeutics

Summary :

Alterity Therapeutics have been granted a patent for compounds able to redistribute excess iron in the brain being developed as a treatment for neurodegenerative diseases including Alzheimer’s and Parkinson’s.


Alterity Therapeutics

Alterity Therapeutics Limited logo

The United States Patent and Trademark Office  has granted Alterity Therapeutics a new composition of matter patent securing a broad monopoly over a new class of iron chaperones, a technology capable of redistributing excess iron in the central nervous system.

Excess iron in the brain is implicated in the pathology of many common neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases (AD and PD, respectively). The structural backbone depicted in the patent provides the foundation for small molecule drug candidates with potential to cross the blood brain barrier and redistribute the labile iron implicated in neurodegeneration.

The patent is entitled “Compounds for and Methods of Treating Diseases” (Application No. 16/818,641). It covers more than 150 novel pharmaceutical compositions and confers 20 years of exclusivity, providing a strong basis for drug development and commercialisation in major neurodegenerative diseases.

The company’s lead clinical candidate ATH434 is a small molecule drug being developed for Multiple System Atrophy (MSA), a form of atypical parkinsonism where iron plays a key role in pathogenesis by promoting α-synuclein aggregation. It has been granted orphan drug designation for the treatment of MSA by the US Food and Drug Administration (FDA) and the European Commission (EC) and is expected to enter a Phase II trial by the end of 2021. The enterprise said the results of this trial and the scientific investigation of ATH434 will augment the development and optimisation of novel compounds expected to emerge from the new patent.

Alterity’s Chief Executive Officer, Dr David Stamler commented: “This new patent is an important part of our corporate strategy to expand our portfolio of potential disease modifying treatments for neurodegenerative diseases affecting many individuals. The newly covered compounds target excess brain iron that is increased in these conditions and we hope to identify a new clinical candidate by the time we get results from our lead clinical programme.”

About  Alterity Therapeutics

Alterity Therapeutics was incorporated in Melbourne, Australia in 1997 as Prana Biotechnology and has offices in Melbourne, Australia, and San Francisco, USA. The Company listed on the Australian Securities Exchange in 2000 and listed on the NASDAQ in 2002.

The company operates under the ticker codes ASX: ATH and NASDAQ: ATHE



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