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2  More Covid Drug in List of WHO Approval.

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WHO, Covid, SAGO, Formation, Members, China, WIV, Maryland, Netherland, Collaborations, Analysis, Pathogen, Scientific, Vietnam, Centre

 Summary :

WHO has recommended two new drugs for COVID-19, providing yet more options for treating the disease. The extent to which these medicines will save lives depends on how widely available and affordable they will be.

The first drug, baricitinib, is strongly recommended for patients with severe or critical COVID-19. It is part of a class of drugs called Janus kinase (JAK) inhibitors that suppress the overstimulation of the immune system. WHO recommends that it is given with corticosteroids.

Baricitinib is an oral drug, used in the treatment of rheumatoid arthritis. It provides an alternative to other arthritis drugs called Interleukin-6 receptor blockers, recommended by WHO in July 2021.

WHO, Covid, SAGO, Formation, Members, China, WIV, Maryland, Netherland, Collaborations, Analysis, Pathogen, Scientific, Vietnam, Centre

2  More Covid Drug in List of WHO Approval.

WHO has also conditionally recommended the use of a monoclonal antibody drug, sotrovimab, for treating mild or moderate COVID-19 in patients who are at high risk of hospitalization. This includes patients who are older, immunocompromised, having underlying conditions like diabetes, hypertension, and obesity, and those unvaccinated.

Sotrovimab is an alternative to casirivimab-imdevimab, a monoclonal antibody cocktail recommended by WHO in September 2021. Studies are ongoing on the effectiveness of monoclonal antibodies against Omicron but early laboratory studies show that sotrovimab retains its activity.

The panel of experts developing the guidelines also looked at two other drugs for severe and critical COVID-19: ruxolitinib and tofacitinib. Given their uncertain effects, WHO made a conditional recommendation against their use.

Today’s recommendations, forming the eighth update of WHO’s living guidelines on therapeutics and COVID-19, are based on evidence from seven trials involving over 4,000 patients with non-severe, severe, and critical COVID-19.

WHO is in discussions with manufacturers to secure global supply capacity and equitable and sustainable access to the newly recommended therapeutics. The Access to COVID-19 Tools Accelerator (ACT-A) Therapeutics pillar has been engaging with pharmaceutical companies to seek comprehensive access plans for low- and middle-income countries, so that these treatments can be rapidly deployed everywhere, not just in rich countries. The ACT-A is also looking to expand licensing scope to make the products more affordable.

The two newly recommended drugs – baricitinib and sotrovimab – have been invited for WHO Prequalification, which assesses the quality, efficacy and safety of priority health products to increase access in lower income countries.

In their recommendation in British medical Journal the BMJ, WHO experts said arthritis drug baricitinib used with corticosteroids to treat severe or critical Covid patients led to better survival rates and reduced need for ventilators.

Experts also recommended synthetic antibody treatment Sotrovimab for people with non-serious Covid at highest risk of hospitalisation, such as the elderly, people with immunodeficiencies or chronic diseases such as diabetes.

Sotrovimab’s benefits for people not at risk of hospitalisation were deemed insignificant and the WHO said its effectiveness against new variants like Omicron was “still uncertain”.

Only three other treatments for Covid-19 have received WHO approval, starting with corticosteroids for severely ill patients in September 2020.

Corticosteroids are inexpensive and widely available and fight inflammation that commonly accompanies severe cases.

Arthritis drugs tocilizumab and sarilumab, which the WHO endorsed in July, are IL-6 inhibitors that suppress a dangerous overreaction of the immune system to the SARS-CoV-2 virus.

 

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